glp-1 shortage update Taking Stock: What Ro's Supply Tracker Reveals about the Drug Shortages GLP-1 Pipeline Update: August 2025

One study (87) provides evidence that pro-GLP-1 prevented apoptosis induced by oxygen-glucose deprivation (OGD) in cultured cortical neurons, and exerted neuroprotective effects through the cAMP/PKA and PI3K/Akt signaling pathways but not the ERK pathway in mice against cerebral ischemia

it is chemically correcting a genetic predisposition toward high-sugar cravings

Adding urgency to this conversation, BMJ meta-analysis found that GLP-1 treatment discontinuation typically occurs within the first year, and that weight regain after stopping can be more rapid than after dietary interventions alone

Cortisol stays elevated