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As summarized in several reviews 7,8,9,10,11 , GRXs are characterized by a thioredoxin fold which consists of a central four-stranded -sheet surrounded by three -helices

doi: 10.1002/ptr.3175

The cyclic ATP is increased, which promotes the mTOR pathway in beta cells, HIF-1 alfa upregulates the transcription of glycolic genes

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