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Chemical modifications and encapsulation techniques, including LNPs, antibody conjugates, fusogenic peptides, and viral vectors, have enhanced RNAi stability and delivery specificity, however sometimes entail compromises in immunogenicity or toxicity

This pathway is influenced by peripheral dopamine activity, as coincubation of dopamine, a GLP-1RA, and a dopamine D2 receptor antagonist increases AMPK phosphorylation and subsequent activation of thermogenesis, likely through a dopamine D1-receptor-mediated mechanism [115]

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