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Mechanism and Rapid Onset (Panel 1) : Succinylcholine triggers a Phase I depolarizing blockade by mimicking acetylcholine, leading to initial muscle fasciculations followed by prolonged membrane depolarization and flaccid paralysis

The main source of intracellular free radicals under basal conditions is from a leakage of superoxide from the mitochondrial respiratory chain.25 Even more importantly, NADPH oxidase-derived superoxide has an important function in pancreatic cancer cell proliferation due to Kras/Rac1-dependent NADPH oxidase induction26 and the importance of this pathway was demonstrated also for liver carcinogenesis.27 Therefore, we were interested whether S

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Time point (i.e., 5, 10, 30, 60 and 120 minutes post-treatment) and treatment type (NLNG vs