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Search strategy We conducted a literature review using the PubMed and Scopus databases to identify studies evaluating PRP use for treating jumper's knee or patellar tendinopathy

Factors that increase estrogen activity include: Low Sex Hormone Binding Globulin (SHBG), which can be caused by blood sugar dysregulation and higher insulin production, allowing higher free estrogen Xenoestrogen exposure (environmental endocrine disruptors like BPA from plastic) Excess adipose (fat) tissue (aromatase activity converts androgens to estrogen in fat cells) Impaired hepatic estrogen metabolism Chronic Inflammation Fibroid tissue has a distinct inflammatory microenvironment

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These trials should also prioritize the development of specific biomarkers to monitor treatment responses and assess drug efficacy in clinical settings