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Finally, the modulation of Nrf2 downstream signaling may be considered as a promising strategy for enhancing the astrocytic production of GSH [108], which may counteract the oxidative imbalance that likely affects neurons in neurodegenerative processes such as PD

Tobacco and Vaping Smoking introduces a massive amount of oxidative stress directly into the lungs and bloodstream

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Although the relationship between glutathione depletion, mitochondrial dysfunction and neuronal cell death needs further exploration, seemingly the clinical improvements in PD patients who are treated with IV glutathione in addition to their traditional medications warrants consideration in appropriate PD patients.