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Exogenous melatonin supplementation can suppress the pineal gland's own output over time

Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW (2021) XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

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Two people can use the same vial, the same dose, and the same schedule, yet get completely different outcomes