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Malinow's concern was based on the result of our study of the Framingham Offspring cohort (38), which showed that, in subjects who were taking vitamin supplements, folic acid fortification was associated with significantly higher serum total homocysteine (tHcy) concentrations than at baseline ( Figure 2 )

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Vitamin B12 Warnings Patients who have early Leber's disease (LHON) a hereditary disease that causes optic nerve atrophy have been found to suffer severe and swift optic atrophy when treated with vitamin B12