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Nonhum Primates Biomed Res

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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

Finally, a considerable problem with GFP-1 receptor agonists is that they can cause a loss of lean (fat-free) body mass