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Description

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets

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Crizanlizumab for the prevention of pain crises in sickle cell disease

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Triple Agonist Design Unlike single- or dual-target peptides, Retatrutide is designed to interact with three receptors simultaneously

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4.3 Glutamine Glutamine (Gln) is mainly converted through GLS/glutamate dehydrogenase (GLUD)-related reactions to generate -KG, which enters the TCA cycle and provides anaplerotic substrates for oxidative metabolism, while also influencing polarization-related epigenetic regulatory processes through metabolic ratios such as -KG/succinate (58)

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