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Synthesis of BGASOs, CAASOs and Atto594ASOs ASOs were obtained from Eurogentec in SEPOP desalted quality or from Biospring in HPLC purified quality

Results SSRIs and SNRIs decrease the neuroinflammation through multiple mechanisms including the reduction of blood or tissue cytokines or regulating complex inflammatory pathways: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), inflammasomes, Toll-like receptor 4 (TLR4), peroxisome proliferator-activated receptor gamma (PPAR)

These may include: Nausea and vomiting Common adverse events as the body adjusts but usually improves over time

Keep the fill volume, resulting concentration and batch number on record for traceability across the protocol, and handle throughout under sterile laboratory conditions