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While HSPA5 upregulation can enhance GPX4 activity and inhibit lipid peroxidation, experimental disruption of this pathway (e.g., via siRNA) blocks DHAs protective effect, allowing its inherent ROS-generating capacity to prevail, ultimately inducing ferroptosis [73]

GLUT5 is expressed in intestine, kidney, testes, skeletal muscle, adipose tissue and brain

Therefore, we identified an important role of Hh signalling in cell survival during Drosophila wing development

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