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Furthermore, the expression of genes associated with mitochondrial biogenesis, including PGC-1, Nrf1, NRF2, and TFAM, was observed to have decreased in brain tissue samples from AD patients (Kerr et al., 2017)

Other Solvents: For some more complex, hydrophobic peptides, solvents like 10% acetic acid might be required to get them into solution

Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency