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Bimagrumab is a drug that was originally developed to treat a condition called muscle wasting, but it was later found to help with weight loss by increasing muscle mass and reducing body fat

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Notably, although tetramers are generated at high protein concentrations, the truncation of either of the two key hydrophobic residues (Leu-344 and Leu-348) can shift the oligomerization state toward the formation of a stable dimer

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