Dysesthesia occurred in 5.1% (4 mg), 12.3% (9 mg), and 12.5% (12 mg) of patients treated with retatrutide, compared to 0.9% with placebo, although this was generally mild to moderate and resolved during treatment
Possible Pathophysiological Pathways of GLP-1 RAs on AUD: Evidence from Mouse Studies In general, GLP-1 receptors are expressed in several tissues in the body and in key brain regions including the VTA, hippocampus, thalamus, hypothalamus, caudate nucleus, and globus pallidus [20]
The resulting consensus provides an integrated synthesis of available evidence, incorporating data from RCTs, systematic reviews, meta-analyses, in vitro , and animal studies
Weight loss has been shown to increase fertility, but losing weight in this way is rarely effective for increasing fertility because it deprives the body of the necessary proteins and fats necessary for hormone production