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Conversely, the downregulation of NRF2 by FTH (ferritin heavy chain), NQO1 (NAD(P)H quinone oxidoreductase-1), and HO-1 (heme oxygenase1) amplified the sensitivity to ferroptosis in HCC [92]

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There has been significant progress toward the identification of the transcriptional, proteomic, and metabolic changes accompanying the induction and development of CI in apples and pears by omics approaches