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14 We were unable to determine the effect on retinopathy from our cohort as many patients received annual screenings outside of our healthcare system, and the results were not adequately documented in our health records

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This chemosensor is expressed by the pancreatic -cells where its signaling activates Gs proteins and induces the secretion of GLP-1 directly through Epac proteins and indirectly via CREB mediated expression of Psck1, while in -cells mediates insulin release [(100)

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