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Nature (1973) 245(5424):3235

The peptide contains three disulfide bonds that must form in the native configuration (Cys6-Cys48, Cys18-Cys61, Cys47-Cys52 in native IGF-1 numbering) to maintain proper three-dimensional folding and receptor binding

A tablet you take consistently beats an injection you stop because of cost or side effects