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5 CRS and biomarkers 5.1 Existing biomarkers in CRS The initial definition of CRS was that it is the outcome of interactions between the renal and other circulatory compartments that increased circulating volume, exacerbated symptoms, and disease progression of patients with HF (Rangaswami et al., 2019)

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Common side effects include nausea, vomiting, diarrhea, and constipation, particularly during dose escalation

Cardiovascular and Drug Interaction Risks Phentermine is a Schedule IV controlled substance that functions as a sympathetic nervous system activator, designed for short-term use (typically 12 weeks or less) due to tolerance and dependency concerns