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Finasteride reduces DHT (root cause)

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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

This targeted mechanism allows enhanced fat oxidation and reduced lipogenesis, particularly in visceral and abdominal fat depots, making it a key subject in obesity and metabolic optimization research