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Clarifying the role of incretin-based therapies in the treatment of type 2 diabetes mellitus

Springer Nature, Singapore (2025)

Standard oral formulations achieve only 0.7% bioavailability, limiting blood level increases compared to IV delivery

Physiology & Behavior 106, 574578.CrossRefGoogle ScholarPubMed Farr, OM, Sofopoulos, M, Tsoukas, MA, Dincer, F, Thakkar, B, Sahin-Efe, A, Filippaios, A, Bowers, J, Srnka, A, Gavrieli, A and Ko, BJ (2016) GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial