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These two features are also reflected by our MTT and CTG assays (Fig

Five Mechanistic Narratives All Plausible, None Sufficient Over the past decade, the field has converged around several mechanistic explanations, each compelling within its own intellectual boundary, yet none capable of integrating the full spectrum of biological effects observed in clinical practice

In some embodiments, the otic formulation or composition comprises about 0.9% by weight of the silicon dioxide

Treatment with AdOx increased the ubiquitination of both ectopically expressed and endogenous GLUD1, demonstrating that the inhibition of GLUD1 methylation facilitated the ubiquitin-dependent degradation of GLUD1 (Fig