glp 1 receptor agonist medicines GLP-1 Agonists and Other Drugs Evolution of GLP‐1 Receptor Agonists

DOI:10.1046/j.1523-1747.1998.00357.x [ Links ] 74

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Originally isolated from human gastric juice, this 15-amino acid compound has been studied in preclinical animal models across multiple physiological systems.*1,9,10

Ideally, quantification of secreted GLP-1 must be based on its concentration immediately at the site of its release in the intestine where it exerts a local effect to activate vagal sensory neurons within the intestinal wall so that vasovagal reflexes important to global metabolic homeostasis can be initiated 26,27