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Additionally, GLP-1 has been shown to enhance the proliferation and differentiation of endothelial progenitor cells through upregulation of VEGF, potentially promoting angiogenesis that could contribute to retinal complications [101,102]

Retatrutide (Future Option) Projected cost: likely $400-$700/month when available Triple-agonist retatrutide awaits FDA approval expected in 2026-2027

Patients report that Ozempic and other similar drugs may be causing health issues such as bowel obstruction, ileus (blocked intestine), cyclic vomiting syndrome, and other issues

No dual or single agonist compound gives researchers access to the GCGR pathway