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The challenge facing this strategy is that monotherapies often have varying pharmacokinetics and pharmacodynamics including half-life [69], meaning that the balance of target-receptor agonism may vary over time when using two different agents with varying profiles

Some have consistent quality and accurate dosing

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Once-weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine 384(11) 2021PMID: 33567185 NEJM 2 Rubino D, Abrahamsson N, Davies M, et al