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Short-term research priorities (35 years): Establish and validate integrated multi-omics-AI diagnostic models

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Pathogenic mutation of the tartrate-resistant acid phosphatase ACP5 leads to a strong predisposition to autoimmune diseases, associated with the accumulation of phosphorylated osteopontin, involved in immune regulation and in bone resorption (138)

To prevent deficiency-related complications, health organizations, including the National Institutes of Health (NIH) and the European Food Safety Authority (EFSA), recommend a daily choline intake of 550 mg/day for men and 425 mg/day for women, increasing to 450 mg/day during pregnancy and 550 mg/day during lactation (22)