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Semaglutide is not an instant fix that eliminates hunger within minutes of the first injection

According to FDA-approved labeling and clinical trial data, the following side effects occur most commonly: Gastrointestinal Effects: Nausea (affecting 1544% of patients, with higher rates at Wegovy doses) [3] [4] Diarrhea (reported in 830% of patients) Vomiting (524% incidence) Constipation (occurring in 324% of patients) Abdominal pain (520% of patients) These gastrointestinal symptoms typically emerge during dose escalation and often diminish with continued therapy as physiological adaptation occurs

Paul C, Cather J, Gooderham M, Poulin Y, Mrowietz U, Ferrandiz C,

The first few days are often three times a week, after which it is lowered to one day per week