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Suffice it to say that after issuing a guidance providing flexibility for manufacturing hand sanitizer to meet growing public demand, FDA began to notice a significant uptick in safety concerns with such products, including contamination with methanol, a toxic and potentially lethal substance that resulted in several poisonings and deaths

They may become useful when combined with delivery methods or after transplant surgery

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Lead toxicity Lead (Pb) toxicity is considered as the second most hazardous element after As, which comprises 0.002% of Earth's crust and it does not show any potential benefit in biological systems [19]