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Result Ipamorelin was highly potent for GH release and, uniquely among GHRPs tested, did not raise ACTH or cortisol above GHRH baseline even at doses 200 the GH-release ED

Cellular senescence in ovarian somatic cells, including GCs and stromal cells, may further exacerbate oxidative stress and inflammatory signaling within the follicular niche [80, 81, 82] Together, these interconnected mechanisms and hallmarks of aging suggest that reproductive aging shares common biological pathways with systemic aging, supporting the view that oocyte aging should be considered within a broader geroscience context

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