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Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients

In DKD, ERS is primarily triggered by hyperglycemia, proteinuria, and the presence of AGEs and free fatty acids ( A recent study has revealed that ERS can increase the levels of unsaturated triacylglycerol precursors and reduce lipid droplet formation, leading to tubular injury and fibrosis in renal proximal tubular cell lines and STZ-induced diabetic mouse kidneys (83)

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Recently, metabonomic studies have revealed significant alterations in endogenous metabolites, including amino acids, polyunsaturated fatty acids (PUFAs), myo-inositol, and citrate, in the serum of schizophrenia patients [2][4]