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Lastly, Brachyury expression - often considered a NC marker and required for the differentiation of mesoderm into notochord [3] - was not detected in the human adult NP, which may argue against the hypothesis that both NC and CLCs are derived from the notochord [73]

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Nature 414 , 916920 (2001)

The extracts add a subtle, earthy depth that many find less acidic than a traditional cup of coffee, and it generally packs less of a punch, with most servings containing about half the caffeine of a standard cup