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Endogenous concentrations decline with age, driving research interest in its roles in tissue maintenance, wound repair, and hair follicle biology

Glucagon-like peptide 1 (GLP1) analogues are licensed options for obesity, but new treatments are required to obtain better weight loss and to directly address other co-morbidities, such as non-alcoholic fatty liver disease

Once the substrate is appropriately positioned, the activated serine nucleophile of the catalytic triad (Ser630) can attack the peptide bond between the second and third residue, and form a tetrahedral covalent intermediate

Others might benefit more from therapies targeting specific metabolic pathways or hormonal responses