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Nicotinamide helps regulate sebum production, strengthen the skin barrier, and has anti-inflammatory properties that can improve overall skin health

In animal models, it has been shown preclinically to upregulate growth hormone receptors in tendon fibroblasts, stimulate angiogenesis via the VEGFR2/Akt-eNOS pathway, and modulate nitric oxide signaling, mechanisms that, if they translate to humans, could support tissue repair in a hormonal environment where estrogen-dependent healing capacity is declining

The FDA approval is important, as we currently do not understand what the long-term health risks a patient may be putting themselves at risk of are

And many of them recommend supplements