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After significant weight loss, metabolic adaptation occursthe body's energy expenditure decreases beyond what would be predicted by the loss of body mass alone

Studies are currently examining the role of GLP-1s in conditions such as heart failure with preserved ejection fraction, metabolic dysfunction-associated steatohepatitis, Alzheimers disease, Parkinsons disease, peripheral artery disease, diabetic kidney disease and cancer, and other pharmaceutical manufacturers are expected to apply for similar GLP-1 label expansions in the future

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We take the Michaelis constants from the literature