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GLP-1R agonist analogues with turn-promoting -amino acids are more active than those with helix-promoting -amino acids at the fourth position Non-traditional substitutions can yield GLP-1 analogues that show distinctive behavior and these might also provide insight into agonist conformation

This genome replicated in cell culture and produced robust levels of infectious virus (HCVcc), nearly 10 5 infectious units ml 1 within 48 h in Huh-7.5 cells, which are highly permissive for HCV RNA replication 99

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