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Prolonged exposure to IGF1 LR3 may lead to downregulation of IGF-1 receptors or desensitization of downstream signaling pathways

1 HNMR (300 MHz, DMSO- d 6 ,ppm): H 12.46 (s, 1H, hydrazine-N H ), 11.85 (s, 1H, 4-bromobenzylidene-N=C H ), 8.43 (s, 1H, 4-hydroxy-3-methoxy benzohydrazide-O H ), 7.90 (s, 1H, 4-hydroxy-3-methoxy benzohydrazide-C 2 - H ), 7.68 (m, 4H, 4-bromobenzylidene C 2 , 3,5,6 - H ), 6.53 (brs, 2H, 4-hydroxy-3-methoxy benzohydrazide-C 5,6 - H ), 3.80 (s, 3H, 4-hydroxy-3-methoxy benzohydrazide-OC H 3 )

This 3-year study (N=2,254) enrolled adults with obesity and prediabetes, then randomized them to liraglutide 3.0 mg (Saxenda) or placebo [8]

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