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If you develop a persistent, unexplained change in bowel habit particularly if you are aged 40 or over or have other risk factors your GP may wish to assess you in line with NICE guidance on suspected cancer (NG12), which sets out referral thresholds for persistent bowel changes

Drug interactions Before taking Contrave or phentermine, tell your healthcare provider about any allergies to medication, and all of the medications you take, including prescription drugs, over-the-counter medicines, and vitamins or supplements

Tirzepatide adds GIP receptor activation, making it a dual agonist

A 2023 study, which included a survey of U.S