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274 Donepezil is an acetylcholinesterase inhibitor that promotes the activation of AMPK and inhibits the activation of the NF-B pathway by facilitating the expression of low-density lipoprotein receptor-associated protein 1, thereby reducing inflammation and intestinal epithelial apoptosis in the colon

From this perspective, the hypothesis that bromelain acts as a radiosensitizer and radioprotector becomes suggestive

Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway