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The ability of TLRs to activate transcription factors interferon regulatory factors (IRFs) or nuclear factor-B (NF-B), requires the recruitment of adaptor proteins, including myeloid differentiation primary response gene 88 (MyD88) and Toll/interleukin-1 (IL-1) receptor-domain-containing adaptor-inducing interferon- (TRIF)

Based on findings from the National Institute of Allergy and Infectious Diseases (NIAID), environmental allergens activate immune pathways that worsen inflammation and itching in atopic dermatitis

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This ingredient is widely used in dermatology for treating melasma and post-inflammatory hyperpigmentation