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Stress triggers cortisol elevation, which promotes fat storage particularly in abdominal regions

In Eli Lilly's Phase 2 clinical trial (published in the New England Journal of Medicine, 2023), 338 adults with obesity or overweight (without diabetes) were treated with retatrutide for 48 weeks

Hypoglycaemia, though uncommon with Ozempic alone, can cause irritability and should be monitored, especially with concurrent diabetes medications

This minimizes the risk to the main vial, but introduces its own set of challenges regarding the stability of the solution in a plastic syringe and the increased risk of contamination