It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC
Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and / hydrolases
Vitamin B3 assists in breaking down nutrients and releasing energy
Results vary based on age, insulin resistance, body composition, sleep, nutrition, and activity level