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This helps ensure that Wegovy is safe and appropriate for you

In human umbilical vein endothelial cells (HUVECs) and aortas from ApoE -/- mice, TMAO increased the concentrations of reactive oxygen species (ROS), especially superoxide, by inhibiting the SIRT3-SOD2-mitochondrial ROS signaling pathway (75)

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Metsera said this was consistent with or better than marketed products, which include Novo Nordisks Wegovy and Eli Lillys Zepbound, and other GLP-1/GIP compounds in clinical development