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ESC scientific document group

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Animal studies have shown that moderate-intensity treadmill exercise initiated after CCI reduces anxiety-like behavior, improves hippocampus-dependent spatial memory, and promotes hippocampal proliferation and newborn neuronal survival in mice, although lesion volume and axon degeneration are not altered by exercise, suggesting that carefully titrated and implemented physical activity may be a safe and effective approach that benefits recovery after TBI [120]