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The study by Neelakantan et al

Phosphorylated PXR recruits a transcription repressor protein complex to the regulatory region of the target gene, repressing its transcription (112)

The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it

49 Cumulatively, these findings suggest supplementation with homocysteine-lowering B vitamins may confer benefits even among individuals whose homocysteine does not exceed normal lab reference ranges