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Description

The peptide chains are locked in place, protected from the hydrolysis that would otherwise break them apart molecule by molecule

The 10 mg group saw 21.4% reduction, and the 5 mg group saw 16.0% reduction

Mechanistically, LONP1 silencing not only reduces cellular bioenergetic capacity but also decreases the LC3-II/I ratio and PINK1/Parkin levels, thereby suppressing mitophagy [169, 170] (Fig