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Tirzepatide Semaglutide (Ozempic/Wegovy) activates GLP-1 receptors, which: Slows stomach emptying Reduces appetite Improves insulin sensitivity Typically results in 15-20% weight loss over a year Tirzepatide (Mounjaro/Zepbound) activates both GLP-1 and GIP receptors, which: Provides all semaglutide benefits May have stronger effects on glucose metabolism Often results in 20-25% weight loss over a year Sometimes has fewer gastrointestinal side effects Your optimal choice depends on your specific PCOS presentation

To make the current evidence and gaps explicit, we now include Table 2 summarizing representative ferroptosis-in-AD studies (human, animal, and cellular), indicating which hallmarks were examined and whether selective rescue or checkpoint linkage was established (Bao et al., 2021

They often mean more side effects without additional metabolic benefit

10.1001/jama.2019.3241 134 SingletonV