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In addition, in the same paper, the authors showed that the expression of monocarboxylate transporter (MCT), such as MCT1 and MCT4, are increased by lactate, along with a boost in oxidative phosphorylation (OXPHOS) activity, supporting a quiescent state and a reduced proliferation

11 12 GLP-1s lower blood sugar, blood pressure, body weight, and inflammationall of which reduce strain on the heart and blood vessels 13 GLP-1 receptors are found in the heart and arteries, where they may also improve endothelial function, increase nitric oxide, and reduce oxidative stress, helping stabilize plaque and improve how the heart uses energy, especially during stress

Tumor-associated macrophages and fibroblasts may secrete IGF to activate IGF-IR in cancer cells thereby promoting chemoresistance and radioresistance [187, 188]

Baird and Yamamoto 2020), although the changes of NRF2 are also influenced by factors other than Keap1, such as Bach1 (Xu et al