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Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus and, at higher doses (as Wegovy), for weight management

In contrast, PCOS patients taking metformin over six months reported a mean weight loss of 2.3 kg in a randomized, controlled, double-blinded trial [126]

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By identifying and eliminating statistical outliers such as studies with extreme effect sizes, implausible variances, or opposite effect directions that probably reflected particular population characteristics, measurement problems, or methodological limitations, our sensitivity analyses methodically addressed this heterogeneity