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Together, they address gut inflammation from multiple angles while BPC-157 provides direct central nervous system benefits through its neurotransmitter interactions

APOE4 carriersand particularly people with two copies of the alleleare more likely to develop severe ARIA (Loomis et al., 2024), affecting the riskbenefit tradeoff for treatment with anti-amyloid therapies, although effects of pretreatment on amyloid burden and presence of vascular pathology (e.g., infarcts) need to be better understood, as do differences in risk among non-White populations

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