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In Phase 3 studies, retatrutide has been given as a once-weekly injection, usually starting at 2mg once weekly before increasing gradually every four weeks

( l ) Mean changes in calcium fluorescence of all cells from elPBN in SemaTRAP mice with Sema-responding cells (n = 54 cells, 6 slices, 4 mice) in blue and KCl only responding cells (n = 145 cells, 6 slices, 4 mice) in black